Assay Detail
Functional
CHEMBL909292
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 isolate 5512 with V321 and M46L mutation in CBMCs
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Natural polymorphisms in the human immunodeficiency virus type 2 protease can accelerate time to development of resistance to protease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.64 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL729 | LOPINAVIR | 4.0 | 1 | 9.00 |
| CHEMBL584 | NELFINAVIR | 4.0 | 1 | 7.51 |
| CHEMBL222559 | TIPRANAVIR | 4.0 | 1 | 7.38 |
| CHEMBL5483011 | INDINAVIR | 3.0 | 1 | 7.35 |
| CHEMBL116 | AMPRENAVIR | 4.0 | 1 | 6.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL729 | LOPINAVIR | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL584 | NELFINAVIR | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL222559 | TIPRANAVIR | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL5483011 | INDINAVIR | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL116 | AMPRENAVIR | IC50 | = | 116.0 | nM | 6.94 |