Assay Detail
Functional
CHEMBL909337
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Antibacterial activity against Escherichia coli 0111:B4 assessed as LPS neutralisation by LAL assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Escherichia coli |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Topomimetics of amphipathic beta-sheet and helix-forming bactericidal peptides neutralize lipopolysaccharide endotoxins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.79 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL386394 | — | — | 1 | 7.00 |
| CHEMBL218635 | — | — | 1 | 6.40 |
| CHEMBL439876 | — | — | 1 | 6.16 |
| CHEMBL220485 | — | — | 1 | 5.85 |
| CHEMBL415180 | — | — | 1 | 5.82 |
| CHEMBL218563 | — | — | 1 | 5.80 |
| CHEMBL386609 | — | — | 1 | 5.66 |
| CHEMBL268572 | — | — | 1 | 5.57 |
| CHEMBL376022 | — | — | 1 | 5.51 |
| CHEMBL221949 | — | — | 1 | 5.43 |
| CHEMBL412419 | — | — | 1 | 5.41 |
| CHEMBL374145 | — | — | 1 | 5.33 |
| CHEMBL436771 | — | — | 1 | 5.30 |
| CHEMBL218414 | — | — | 1 | - |
| CHEMBL386610 | — | — | 1 | - |
| CHEMBL220590 | — | — | 1 | - |
| CHEMBL221950 | — | — | 1 | - |
| CHEMBL414812 | — | — | 1 | - |
| CHEMBL221186 | OTX-008 | 1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL386394 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL218635 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL439876 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL220485 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL415180 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL218563 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL386609 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL268572 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL376022 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL221949 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL412419 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL374145 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL436771 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL218414 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL386610 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL220590 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL221950 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL414812 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL221186 | OTX-008 | IC50 | > | 5000.0 | nM | - |