Assay Detail
Binding
CHEMBL909387
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Displacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cells
14
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL298) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Partial retro-inverso, retro, and inverso modifications of hydrazide linked bifunctional peptides for opioid and cholecystokinin (CCK) receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.46 | 6.77 |
| Ki | 7 | 5.81 | 7.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL217957 | — | — | 2 | 7.15 |
| CHEMBL218600 | — | — | 2 | 5.96 |
| CHEMBL386212 | — | — | 2 | 5.11 |
| CHEMBL407198 | — | — | 2 | 5.03 |
| CHEMBL414087 | — | — | 2 | 5.00 |
| CHEMBL218651 | — | — | 2 | 4.87 |
| CHEMBL386186 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL217957 | — | Ki | = | 71.0 | nM | 7.15 |
| CHEMBL217957 | — | IC50 | = | 169.82 | nM | 6.77 |
| CHEMBL218600 | — | IC50 | = | 1096.48 | nM | 5.96 |
| CHEMBL218600 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL386212 | — | IC50 | = | 7762.47 | nM | 5.11 |
| CHEMBL386212 | — | Ki | = | 7700.0 | nM | 5.11 |
| CHEMBL407198 | — | IC50 | = | 9332.54 | nM | 5.03 |
| CHEMBL407198 | — | Ki | = | 9300.0 | nM | 5.03 |
| CHEMBL414087 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL218651 | — | IC50 | = | 13489.63 | nM | 4.87 |
| CHEMBL414087 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL386186 | — | IC50 | = | 66069344.8 | nM | - |
| CHEMBL386186 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL218651 | — | Ki | > | 10000.0 | nM | - |