Compound Detail

CHEMBL217957

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CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc1cc2ccccc2[nH]1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL217957
Phase	Preclinical
Structure Type	MOL
InChI Key	FEOAQCGOOODCEB-RXFVQNAMSA-N

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

Molecular Properties

1132.3

MW (Da)

Drug Information

Molecule Type	Small molecule
Availability	Unknown
Chirality	Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula	C58H73N11O13
MW	1132.29

Activity Summary

IC50 8 meas. best 8.86

Ki 3 meas. best 9.2

EC50 2 meas. best 8.23

Target Activity Profile

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
Delta-type opioid receptor CHEMBL236	Ki	9.2	9.2	0.6	1
Delta-type opioid receptor CHEMBL236	IC50	8.86	8.545	1.4	2
Delta-type opioid receptor CHEMBL236	EC50	8.23	8.23	5.9	1
Delta-type opioid receptor CHEMBL3222	IC50	7.8	7.8	16.0	1
Mu-type opioid receptor CHEMBL270	Ki	7.28	7.28	52.0	1
Gastrin/cholecystokinin type B receptor CHEMBL298	Ki	7.15	7.15	71.0	1
Mu-type opioid receptor CHEMBL270	IC50	6.92	6.56	120.2	2
Gastrin/cholecystokinin type B receptor CHEMBL298	IC50	6.77	6.77	169.8	1
Mu-type opioid receptor CHEMBL4354	IC50	6.62	6.62	240.0	1
Mu-type opioid receptor CHEMBL270	EC50	6.2	6.2	630.0	1

Activity Data Samples

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
Delta-type opioid receptor	Ki	=	0.63	nM	9.2	Displacement of [3H]DPDPE from human delta opioid receptor expressed in HN9.10 c...	17201419
Delta-type opioid receptor	IC50	=	1.38	nM	8.86	Displacement of [3H]DPDPE from human delta opioid receptor expressed in HN9.10 c...	17201419
Delta-type opioid receptor	EC50	=	5.9	nM	8.23	Activity at human delta opioid receptor expressed in CHO cells by [35S]GTP-gamma...	17201419
Delta-type opioid receptor	IC50	=	5.888	nM	8.23	Activity at human delta opioid receptor expressed in CHO cells by [35S]GTP-gamma...	17201419
Delta-type opioid receptor	IC50	=	16.0	nM	7.8	Activity at delta opioid receptor in ICR mouse by MVD assay	17201419
Mu-type opioid receptor	Ki	=	52.0	nM	7.28	Displacement of [3H]DAMGO from rat mu opioid receptor expressed in HN9.10 cells	17201419
Gastrin/cholecystokinin type B receptor	Ki	=	71.0	nM	7.15	Displacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cell...	17201419
Mu-type opioid receptor	IC50	=	120.23	nM	6.92	Displacement of [3H]DAMGO from rat mu opioid receptor expressed in HN9.10 cells	17201419
Gastrin/cholecystokinin type B receptor	IC50	=	169.82	nM	6.77	Displacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cell...	17201419
Mu-type opioid receptor	IC50	=	240.0	nM	6.62	Activity at mu opioid receptor assessed as contraction of electrically-stimulate...	17201419
Mu-type opioid receptor	EC50	=	630.0	nM	6.2	Activity at rat mu opioid receptor expressed in CHO cells by [35S]GTPgammaS bind...	17201419
Mu-type opioid receptor	IC50	=	630.96	nM	6.2	Activity at rat mu opioid receptor expressed in CHO cells by [35S]GTPgammaS bind...	17201419

Literature References

PubMed	DOI	Target Context	# Activities
17201419	10.1021/jm061268p	Delta-type opioid receptor	6
17201419	10.1021/jm061268p	Mu-type opioid receptor	6
17201419	10.1021/jm061268p	Cholecystokinin receptor type A	3
17201419	10.1021/jm061268p	Gastrin/cholecystokinin type B receptor	2
17201419	10.1021/jm061268p	Unchecked	2

Data from ChEMBL 36 via Core Engine