Assay Detail
Functional
CHEMBL911101
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity at mu opioid receptor assessed as contraction of electrically-stimulated Hartley guinea pig ileum
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Partial retro-inverso, retro, and inverso modifications of hydrazide linked bifunctional peptides for opioid and cholecystokinin (CCK) receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.91 | 8.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL200199 | BIPHALIN | — | 1 | 8.06 |
| CHEMBL218651 | — | — | 1 | 7.12 |
| CHEMBL407198 | — | — | 1 | 7.09 |
| CHEMBL386212 | — | — | 1 | 7.03 |
| CHEMBL375359 | — | — | 1 | 7.01 |
| CHEMBL386186 | — | — | 1 | 6.68 |
| CHEMBL217957 | — | — | 1 | 6.62 |
| CHEMBL414087 | — | — | 1 | 6.34 |
| CHEMBL218600 | — | — | 1 | 6.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL200199 | BIPHALIN | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL218651 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL407198 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL386212 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL375359 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL386186 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL217957 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL414087 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL218600 | — | IC50 | = | 530.0 | nM | 6.28 |