Assay Detail
Binding
CHEMBL911094
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DAMGO from rat mu opioid receptor expressed in HN9.10 cells
16
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Partial retro-inverso, retro, and inverso modifications of hydrazide linked bifunctional peptides for opioid and cholecystokinin (CCK) receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.96 | 9.30 |
| IC50 | 8 | 7.60 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL407198 | — | — | 2 | 9.30 |
| CHEMBL375359 | — | — | 2 | 8.52 |
| CHEMBL218651 | — | — | 2 | 8.47 |
| CHEMBL386212 | — | — | 2 | 7.89 |
| CHEMBL414087 | — | — | 2 | 7.51 |
| CHEMBL386186 | — | — | 2 | 7.47 |
| CHEMBL217957 | — | — | 2 | 7.28 |
| CHEMBL218600 | — | — | 2 | 7.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL407198 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL407198 | — | IC50 | = | 1.202 | nM | 8.92 |
| CHEMBL375359 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL218651 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL375359 | — | IC50 | = | 6.918 | nM | 8.16 |
| CHEMBL218651 | — | IC50 | = | 7.943 | nM | 8.10 |
| CHEMBL386212 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL386212 | — | IC50 | = | 28.84 | nM | 7.54 |
| CHEMBL414087 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL386186 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL217957 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL218600 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL414087 | — | IC50 | = | 64.57 | nM | 7.19 |
| CHEMBL386186 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL217957 | — | IC50 | = | 120.23 | nM | 6.92 |
| CHEMBL218600 | — | IC50 | = | 131.83 | nM | 6.88 |