Assay Detail
Binding
CHEMBL909447
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of FAM-Bid from human Mcl1 by FP assay
5
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Induced myeloid leukemia cell differentiation protein Mcl-1 (CHEMBL4361) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.08 | 7.92 |
| IC50 | 2 | 6.64 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL410802 | — | — | 2 | 7.92 |
| CHEMBL51483 | GOSSYPOL | 3.0 | 1 | 6.75 |
| CHEMBL217354 | — | — | 2 | 6.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL410802 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL410802 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL51483 | GOSSYPOL | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL217354 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL217354 | — | IC50 | = | 1030.0 | nM | 5.99 |