Compound Detail
CHEMBL410802
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Basic Information
| ChEMBL ID | CHEMBL410802 |
| Phase | Preclinical |
| Structure Type | BOTH |
| InChI Key | LBBXBBBHAYODPZ-GVIMSCNFSA-N |
3
Targets
5
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
2437.7
MW (Da)
Drug Information
| Molecule Type | Protein |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 8.15
IC50 2 meas. best 7.28
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Bcl-2-like protein 1 CHEMBL4625 | Ki | 8.15 | 8.15 | 7.0 | 1 |
| Apoptosis regulator Bcl-2 CHEMBL4860 | Ki | 7.96 | 7.96 | 11.0 | 1 |
| Induced myeloid leukemia cell differentiation protein Mcl-1 CHEMBL4361 | Ki | 7.92 | 7.92 | 12.0 | 1 |
| Induced myeloid leukemia cell differentiation protein Mcl-1 CHEMBL4361 | IC50 | 7.28 | 7.28 | 52.0 | 1 |
| Bcl-2-like protein 1 CHEMBL4625 | IC50 | 7.19 | 7.19 | 65.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Bcl-2-like protein 1 | Ki | = | 7.0 | nM | 8.15 | Displacement of FAM-Bak from human Bcl-xL by FP assay | 17034116 |
| Apoptosis regulator Bcl-2 | Ki | = | 11.0 | nM | 7.96 | Displacement of FAM-Bid from human Bcl2 by FP assay | 17034116 |
| Induced myeloid leukemia cell differentiation protein Mcl-1 | Ki | = | 12.0 | nM | 7.92 | Displacement of FAM-Bid from human Mcl1 by FP assay | 17034116 |
| Induced myeloid leukemia cell differentiation protein Mcl-1 | IC50 | = | 52.0 | nM | 7.28 | Displacement of FAM-Bid from human Mcl1 by FP assay | 17034116 |
| Bcl-2-like protein 1 | IC50 | = | 65.0 | nM | 7.19 | Displacement of FAM-Bak from human Bcl-xL by FP assay | 17034116 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17034116 | 10.1021/jm060460o | Bcl-2-like protein 1 | 2 |
| 17034116 | 10.1021/jm060460o | Induced myeloid leukemia cell differentiation protein Mcl-1 | 2 |
| 17034116 | 10.1021/jm060460o | Apoptosis regulator Bcl-2 | 1 |
Data from ChEMBL 36 via Core Engine