Assay Detail
Binding
CHEMBL909446
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Displacement of FAM-Bak from human Bcl-xL by FP assay
5
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.81 | 8.15 |
| IC50 | 2 | 6.19 | 7.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL410802 | — | — | 2 | 8.15 |
| CHEMBL51483 | GOSSYPOL | 3.0 | 1 | 6.32 |
| CHEMBL217354 | — | — | 2 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL410802 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL410802 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL51483 | GOSSYPOL | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL217354 | — | Ki | = | 1110.0 | nM | 5.96 |
| CHEMBL217354 | — | IC50 | = | 6580.0 | nM | 5.18 |