Assay Detail
Functional
CHEMBL909615
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Reversal of cytokine withdrawal protection in IL3 dependent Bcl-xL overexpressing mouse FL5.12 cells in presence of bovine gelatin
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | FL5.12 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 7.08 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL376409 | — | — | 1 | 7.66 |
| CHEMBL376408 | ABT 737 | 1.0 | 1 | 7.52 |
| CHEMBL384218 | — | — | 1 | 7.52 |
| CHEMBL376410 | — | — | 1 | 7.40 |
| CHEMBL218524 | — | — | 1 | 7.25 |
| CHEMBL217960 | — | — | 1 | 6.89 |
| CHEMBL218408 | — | — | 1 | 6.75 |
| CHEMBL384217 | — | — | 1 | 6.42 |
| CHEMBL266944 | — | — | 1 | 6.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL376409 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL376408 | ABT 737 | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL384218 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL376410 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL218524 | — | EC50 | = | 56.0 | nM | 7.25 |
| CHEMBL217960 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL218408 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL384217 | — | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL266944 | — | EC50 | = | 460.0 | nM | 6.34 |