Assay Detail
Functional
CHEMBL909616
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Reversal of cytokine withdrawal protection in IL3 dependent Bcl-xL overexpressing mouse FL5.12 cells in presence of 3% FBS
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | FL5.12 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 5.97 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL376410 | — | — | 1 | 6.92 |
| CHEMBL376409 | — | — | 1 | 6.92 |
| CHEMBL376408 | ABT 737 | 1.0 | 1 | 6.66 |
| CHEMBL384218 | — | — | 1 | 6.16 |
| CHEMBL217960 | — | — | 1 | 6.15 |
| CHEMBL374309 | — | — | 1 | 5.92 |
| CHEMBL218524 | — | — | 1 | 5.60 |
| CHEMBL218408 | — | — | 1 | 5.55 |
| CHEMBL384217 | — | — | 1 | 5.35 |
| CHEMBL192571 | — | — | 1 | 5.29 |
| CHEMBL266944 | — | — | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL376410 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL376409 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL376408 | ABT 737 | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL384218 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL217960 | — | EC50 | = | 710.0 | nM | 6.15 |
| CHEMBL374309 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL218524 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL218408 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL384217 | — | EC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL192571 | — | EC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL266944 | — | EC50 | = | 6700.0 | nM | 5.17 |