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Assay Detail

CHEMBL909618

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of LPS-induced NF-kappaB production in HEK293 cells
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HEK293
Confidence 1 — Organism
Curated By Autocuration

Target

HEK293 (CHEMBL614818)
Type CELL-LINE
Organism Homo sapiens

Publication

Polycationic sulfonamides for the sequestration of endotoxin.
Burns MR, Jenkins SA, Kimbrell MR, Balakrishna R, Nguyen TB, Abbo BG, David SA.
J Med Chem (2007) 50 : 877 -888
PubMed 17256835 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 37 5.65 6.72

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL221243 1 6.72
CHEMBL375009 1 6.70
CHEMBL221242 1 6.56
CHEMBL384590 1 6.55
CHEMBL374052 1 6.52
CHEMBL219221 1 6.44
CHEMBL218282 1 6.44
CHEMBL218271 1 6.42
CHEMBL218434 1 6.39
CHEMBL218163 1 6.30
CHEMBL217906 1 6.28
CHEMBL386494 1 6.22
CHEMBL375541 1 6.17
CHEMBL374062 1 6.16
CHEMBL218283 1 6.09
CHEMBL220552 1 5.97
CHEMBL220744 1 5.66
CHEMBL374054 1 5.57
CHEMBL218264 1 5.57
CHEMBL219107 1 5.50
CHEMBL217939 1 5.38
CHEMBL373829 1 5.31
CHEMBL374583 1 5.29
CHEMBL375322 1 5.25
CHEMBL196566 1 5.19
CHEMBL218322 1 5.04
CHEMBL425463 1 5.01
CHEMBL221682 1 4.99
CHEMBL375184 1 4.93
CHEMBL218112 1 4.90

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL221243 IC50 = 190.0 nM 6.72
CHEMBL375009 IC50 = 200.0 nM 6.70
CHEMBL221242 IC50 = 278.0 nM 6.56
CHEMBL384590 IC50 = 280.0 nM 6.55
CHEMBL374052 IC50 = 300.0 nM 6.52
CHEMBL219221 IC50 = 363.0 nM 6.44
CHEMBL218282 IC50 = 360.0 nM 6.44
CHEMBL218271 IC50 = 379.0 nM 6.42
CHEMBL218434 IC50 = 410.0 nM 6.39
CHEMBL218163 IC50 = 500.0 nM 6.30
CHEMBL217906 IC50 = 522.0 nM 6.28
CHEMBL386494 IC50 = 607.0 nM 6.22
CHEMBL375541 IC50 = 669.0 nM 6.17
CHEMBL374062 IC50 = 686.0 nM 6.16
CHEMBL218283 IC50 = 816.0 nM 6.09
CHEMBL220552 IC50 = 1060.0 nM 5.97
CHEMBL220744 IC50 = 2200.0 nM 5.66
CHEMBL218264 IC50 = 2680.0 nM 5.57
CHEMBL374054 IC50 = 2680.0 nM 5.57
CHEMBL219107 IC50 = 3170.0 nM 5.50
CHEMBL217939 IC50 = 4200.0 nM 5.38
CHEMBL373829 IC50 = 4850.0 nM 5.31
CHEMBL374583 IC50 = 5170.0 nM 5.29
CHEMBL375322 IC50 = 5560.0 nM 5.25
CHEMBL196566 IC50 = 6490.0 nM 5.19
CHEMBL218322 IC50 = 9190.0 nM 5.04
CHEMBL425463 IC50 = 9760.0 nM 5.01
CHEMBL221682 IC50 = 10300.0 nM 4.99
CHEMBL375184 IC50 = 11700.0 nM 4.93
CHEMBL218112 IC50 = 12720.0 nM 4.90
CHEMBL222166 IC50 = 13200.0 nM 4.88
CHEMBL218599 IC50 = 13800.0 nM 4.86
CHEMBL374053 IC50 = 16400.0 nM 4.79
CHEMBL222162 IC50 = 22400.0 nM 4.65
CHEMBL218232 IC50 = 33300.0 nM 4.48
CHEMBL374051 IC50 = 64000.0 nM 4.19
CHEMBL425812 IC50 = 200000.0 nM -