Assay Detail
Functional
CHEMBL909620
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Inhibition of LPS-induced TNFalpha release in human whole blood
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Polycationic sulfonamides for the sequestration of endotoxin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.70 | 4.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL374052 | — | — | 1 | 4.96 |
| CHEMBL375009 | — | — | 1 | 4.85 |
| CHEMBL218282 | — | — | 1 | 4.75 |
| CHEMBL384590 | — | — | 1 | 4.66 |
| CHEMBL221243 | — | — | 1 | 4.52 |
| CHEMBL221242 | — | — | 1 | 4.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL374052 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL375009 | — | IC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL218282 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL384590 | — | IC50 | = | 22100.0 | nM | 4.66 |
| CHEMBL221243 | — | IC50 | = | 30100.0 | nM | 4.52 |
| CHEMBL221242 | — | IC50 | = | 32900.0 | nM | 4.48 |