Assay Detail
Binding
CHEMBL909830
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant SIRT2 by radioactive deacetylase assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
NAD-dependent protein deacetylase sirtuin-2 (CHEMBL4462) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.13 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6291 | BISINDOLYLMALEIMIDE IX | — | 1 | 5.96 |
| CHEMBL430574 | PAULLONE | — | 1 | 5.00 |
| CHEMBL7463 | GF-109203 | — | 1 | 4.93 |
| CHEMBL291725 | — | — | 1 | 4.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6291 | BISINDOLYLMALEIMIDE IX | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL430574 | PAULLONE | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL7463 | GF-109203 | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL291725 | — | IC50 | = | 24100.0 | nM | 4.62 |