Assay Detail
Functional
CHEMBL909889
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Inhibition of HCT116 cell proliferation (mean)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Identification of a potent and stable antiproliferative agent by the prodrug formation of a thiolate histone deacetylase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 5.76 | 6.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL217563 | — | — | 1 | 6.21 |
| CHEMBL261960 | — | — | 1 | 6.12 |
| CHEMBL384522 | — | — | 1 | 5.92 |
| CHEMBL368036 | — | — | 1 | 5.89 |
| CHEMBL217338 | — | — | 1 | 4.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL217563 | — | EC50 | = | 620.0 | nM | 6.21 |
| CHEMBL261960 | — | EC50 | = | 750.0 | nM | 6.12 |
| CHEMBL384522 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL368036 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL217338 | — | EC50 | = | 23000.0 | nM | 4.64 |