Assay Detail
Binding
CHEMBL909896
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Inhibition of mouse 11beta-HSD1 expressed in Escherichia coli by SPA
23
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
11-beta-hydroxysteroid dehydrogenase 1 (CHEMBL3910) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Discovery and metabolic stabilization of potent and selective 2-amino-N-(adamant-2-yl) acetamide 11beta-hydroxysteroid dehydrogenase type 1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 7.32 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL375341 | — | — | 1 | 8.70 |
| CHEMBL425104 | — | — | 2 | 8.30 |
| CHEMBL374728 | — | — | 1 | 8.30 |
| CHEMBL217917 | — | — | 1 | 8.15 |
| CHEMBL424937 | — | — | 1 | 8.10 |
| CHEMBL415429 | — | — | 1 | 8.05 |
| CHEMBL375156 | — | — | 1 | 7.82 |
| CHEMBL218144 | — | — | 1 | 7.75 |
| CHEMBL218093 | — | — | 1 | 7.68 |
| CHEMBL218758 | — | — | 1 | 7.62 |
| CHEMBL218197 | — | — | 1 | 7.48 |
| CHEMBL219142 | — | — | 1 | 7.47 |
| CHEMBL218142 | — | — | 1 | 7.29 |
| CHEMBL384364 | — | — | 1 | 7.28 |
| CHEMBL218143 | — | — | 1 | 6.96 |
| CHEMBL218358 | — | — | 1 | 6.96 |
| CHEMBL386029 | — | — | 1 | 6.92 |
| CHEMBL219443 | — | — | 1 | 6.75 |
| CHEMBL373889 | — | — | 1 | 6.52 |
| CHEMBL374922 | — | — | 1 | 6.33 |
| CHEMBL219494 | — | — | 1 | 6.04 |
| CHEMBL218096 | — | — | 1 | 5.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL375341 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL425104 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL374728 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL217917 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL424937 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL415429 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL375156 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL218144 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL218093 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL218758 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL218197 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL219142 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL218142 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL384364 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL218358 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL218143 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL386029 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL219443 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL425104 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL373889 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL374922 | — | Ki | = | 470.0 | nM | 6.33 |
| CHEMBL219494 | — | Ki | = | 910.0 | nM | 6.04 |
| CHEMBL218096 | — | Ki | = | 4100.0 | nM | 5.39 |