Compound Detail
CHEMBL425104
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C[C@@H](C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2)N1CCN(c2ccc(C(F)(F)F)cn2)CC1
Basic Information
| ChEMBL ID | CHEMBL425104 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RSIROJJHJFVYIR-BXNVBKHCSA-N |
2
Targets
6
Activities
2
Assay Types
4
PK Parameters
3
Publications
0
Known Names
Molecular Properties
452.5
MW (Da)
2.67
ALogP
5
HBA
2
HBD
68.7
PSA (Ų)
0.74
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 4 meas. best 8.4
IC50 2 meas. best 7.58
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 11-beta-hydroxysteroid dehydrogenase 1 CHEMBL4235 | Ki | 8.4 | 8.275 | 4.0 | 2 |
| 11-beta-hydroxysteroid dehydrogenase 1 CHEMBL3910 | Ki | 8.3 | 7.44 | 5.0 | 2 |
| 11-beta-hydroxysteroid dehydrogenase 1 CHEMBL4235 | IC50 | 7.58 | 7.51 | 26.0 | 2 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 16.67 | mL.min-1.kg-1 | Homo sapiens |
| CL | 33.33 | mL.min-1.kg-1 | Homo sapiens |
| CL | 100.0 | mL.min-1.kg-1 | Mus musculus |
| CL | 266.67 | mL.min-1.kg-1 | Mus musculus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 11-beta-hydroxysteroid dehydrogenase 1 | Ki | = | 4.0 | nM | 8.4 | Inhibition of human 11beta-HSD1 expressed in Escherichia coli by SPA | 17201418 |
| 11-beta-hydroxysteroid dehydrogenase 1 | Ki | = | 5.0 | nM | 8.3 | Inhibition of mouse 11beta-HSD1 expressed in Escherichia coli by SPA | 17201418 |
| 11-beta-hydroxysteroid dehydrogenase 1 | Ki | = | 7.0 | nM | 8.15 | Inhibition of human 11beta-HSD1 expressed in Escherichia coli by SPA | 17201418 |
| 11-beta-hydroxysteroid dehydrogenase 1 | IC50 | = | 26.0 | nM | 7.58 | Inhibition of human 11beta-HSD1 expressed in HEK293 cells by FPIA | 17201418 |
| 11-beta-hydroxysteroid dehydrogenase 1 | IC50 | = | 36.0 | nM | 7.44 | Inhibition of human 11beta-HSD1 expressed in HEK293 cells by FPIA | 17201418 |
| 11-beta-hydroxysteroid dehydrogenase 1 | Ki | = | 260.0 | nM | 6.58 | Inhibition of mouse 11beta-HSD1 expressed in Escherichia coli by SPA | 17201418 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17201418 | 10.1021/jm0609364 | 11-beta-hydroxysteroid dehydrogenase 1 | 6 |
| 17201418 | 10.1021/jm0609364 | Liver microsomes | 2 |
| 17201418 | 10.1021/jm0609364 | ADMET | 2 |
Data from ChEMBL 36 via Core Engine