Assay Detail
Binding
CHEMBL909955
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Binding affinity to human caspase 3
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
5-pyrrolidinylsulfonyl isatins as a potential tool for the molecular imaging of caspases in apoptosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 8.23 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL213759 | — | — | 1 | 9.70 |
| CHEMBL216071 | — | — | 1 | 9.10 |
| CHEMBL216819 | — | — | 1 | 8.92 |
| CHEMBL384023 | — | — | 1 | 8.92 |
| CHEMBL387041 | — | — | 1 | 8.72 |
| CHEMBL200927 | — | — | 1 | 8.40 |
| CHEMBL200677 | — | — | 1 | 8.32 |
| CHEMBL217457 | — | — | 1 | 8.23 |
| CHEMBL216447 | — | — | 1 | 8.10 |
| CHEMBL62993 | — | — | 1 | 8.08 |
| CHEMBL386510 | — | — | 1 | 8.07 |
| CHEMBL217777 | — | — | 1 | 8.05 |
| CHEMBL217821 | — | — | 1 | 8.01 |
| CHEMBL217822 | (S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]-1-(4-(tributylstannyl)benzyl)isatin | — | 1 | 7.90 |
| CHEMBL385930 | — | — | 1 | 7.90 |
| CHEMBL215480 | — | — | 1 | 7.75 |
| CHEMBL217220 | — | — | 1 | 7.63 |
| CHEMBL60190 | — | — | 1 | 7.38 |
| CHEMBL293034 | — | — | 1 | 7.25 |
| CHEMBL386464 | (S)-5-[1-(2-phenoxymethylpyrrolidinyl)sulfonyl]-1-(4-(tributylstannyl)benzyl)isatin | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL213759 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL216071 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL216819 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL384023 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL387041 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL200927 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL200677 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL217457 | — | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL216447 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL62993 | — | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL386510 | — | Ki | = | 8.6 | nM | 8.07 |
| CHEMBL217777 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL217821 | — | Ki | = | 9.8 | nM | 8.01 |
| CHEMBL217822 | (S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]-1-(4-(tributylstannyl)benzyl)isatin | Ki | = | 12.6 | nM | 7.90 |
| CHEMBL385930 | — | Ki | = | 12.6 | nM | 7.90 |
| CHEMBL215480 | — | Ki | = | 17.9 | nM | 7.75 |
| CHEMBL217220 | — | Ki | = | 23.5 | nM | 7.63 |
| CHEMBL60190 | — | Ki | = | 41.8 | nM | 7.38 |
| CHEMBL293034 | — | Ki | = | 56.1 | nM | 7.25 |
| CHEMBL386464 | (S)-5-[1-(2-phenoxymethylpyrrolidinyl)sulfonyl]-1-(4-(tributylstannyl)benzyl)isatin | Ki | > | 5000.0 | nM | - |