Assay Detail
Binding
CHEMBL909966
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Inhibition of caspase 3
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
5-pyrrolidinylsulfonyl isatins as a potential tool for the molecular imaging of caspases in apoptosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.93 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL213759 | — | — | 1 | 9.52 |
| CHEMBL216071 | — | — | 1 | 8.77 |
| CHEMBL216819 | — | — | 1 | 8.62 |
| CHEMBL384023 | — | — | 1 | 8.62 |
| CHEMBL387041 | — | — | 1 | 8.42 |
| CHEMBL200927 | — | — | 1 | 8.09 |
| CHEMBL200677 | — | — | 1 | 8.01 |
| CHEMBL217457 | — | — | 1 | 7.92 |
| CHEMBL216447 | — | — | 1 | 7.79 |
| CHEMBL62993 | — | — | 1 | 7.77 |
| CHEMBL386510 | — | — | 1 | 7.76 |
| CHEMBL217777 | — | — | 1 | 7.74 |
| CHEMBL217821 | — | — | 1 | 7.70 |
| CHEMBL217822 | (S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]-1-(4-(tributylstannyl)benzyl)isatin | — | 1 | 7.59 |
| CHEMBL385930 | — | — | 1 | 7.59 |
| CHEMBL215480 | — | — | 1 | 7.44 |
| CHEMBL217220 | — | — | 1 | 7.32 |
| CHEMBL60190 | — | — | 1 | 7.07 |
| CHEMBL293034 | — | — | 1 | 6.94 |
| CHEMBL386464 | (S)-5-[1-(2-phenoxymethylpyrrolidinyl)sulfonyl]-1-(4-(tributylstannyl)benzyl)isatin | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL213759 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL216071 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL216819 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL384023 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL387041 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL200927 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL200677 | — | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL217457 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL216447 | — | IC50 | = | 16.3 | nM | 7.79 |
| CHEMBL62993 | — | IC50 | = | 16.9 | nM | 7.77 |
| CHEMBL386510 | — | IC50 | = | 17.5 | nM | 7.76 |
| CHEMBL217777 | — | IC50 | = | 18.4 | nM | 7.74 |
| CHEMBL217821 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL217822 | (S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]-1-(4-(tributylstannyl)benzyl)isatin | IC50 | = | 25.5 | nM | 7.59 |
| CHEMBL385930 | — | IC50 | = | 25.6 | nM | 7.59 |
| CHEMBL215480 | — | IC50 | = | 36.4 | nM | 7.44 |
| CHEMBL217220 | — | IC50 | = | 47.8 | nM | 7.32 |
| CHEMBL60190 | — | IC50 | = | 84.9 | nM | 7.07 |
| CHEMBL293034 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL386464 | (S)-5-[1-(2-phenoxymethylpyrrolidinyl)sulfonyl]-1-(4-(tributylstannyl)benzyl)isatin | IC50 | > | 10000.0 | nM | - |