Assay Detail
Binding
CHEMBL909970
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]glycine from Gly/NMDA receptor in rat cortical synaptic membrane
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Structural investigation of the 7-chloro-3-hydroxy-1H-quinazoline-2,4-dione scaffold to obtain AMPA and kainate receptor selective antagonists. Synthesis, pharmacological, and molecular modeling studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 4.91 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL80594 | — | — | 1 | 6.62 |
| CHEMBL385438 | — | — | 1 | 6.00 |
| CHEMBL385648 | — | — | 1 | 4.64 |
| CHEMBL217826 | — | — | 1 | 4.60 |
| CHEMBL386418 | — | — | 1 | 4.38 |
| CHEMBL218290 | — | — | 1 | 4.06 |
| CHEMBL217073 | — | — | 1 | 4.05 |
| CHEMBL387049 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL80594 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL385438 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL385648 | — | Ki | = | 22700.0 | nM | 4.64 |
| CHEMBL217826 | — | Ki | = | 25000.0 | nM | 4.60 |
| CHEMBL386418 | — | Ki | = | 42000.0 | nM | 4.38 |
| CHEMBL218290 | — | Ki | = | 88000.0 | nM | 4.06 |
| CHEMBL217073 | — | Ki | = | 90000.0 | nM | 4.05 |
| CHEMBL387049 | — | Ki | > | 30000.0 | nM | - |