Assay Detail
Binding
CHEMBL909971
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]KA from high affinity KA receptor in rat cortical membrane
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structural investigation of the 7-chloro-3-hydroxy-1H-quinazoline-2,4-dione scaffold to obtain AMPA and kainate receptor selective antagonists. Synthesis, pharmacological, and molecular modeling studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.91 | 6.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL387402 | — | — | 1 | 6.21 |
| CHEMBL217826 | — | — | 1 | 5.39 |
| CHEMBL217551 | — | — | 1 | 5.27 |
| CHEMBL385648 | — | — | 1 | 5.21 |
| CHEMBL310286 | — | — | 1 | 5.16 |
| CHEMBL385438 | — | — | 1 | 5.09 |
| CHEMBL386418 | — | — | 1 | 5.00 |
| CHEMBL217519 | — | — | 1 | 4.89 |
| CHEMBL438473 | — | — | 1 | 4.89 |
| CHEMBL372797 | — | — | 1 | 4.34 |
| CHEMBL384572 | — | — | 1 | 4.28 |
| CHEMBL387049 | — | — | 1 | 4.09 |
| CHEMBL216390 | — | — | 1 | 4.00 |
| CHEMBL80594 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL387402 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL217826 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL217551 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL385648 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL310286 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL385438 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL386418 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL217519 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL438473 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL372797 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL384572 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL387049 | — | IC50 | = | 81000.0 | nM | 4.09 |
| CHEMBL216390 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL80594 | — | IC50 | = | 140000.0 | nM | - |