Compound Detail
CHEMBL216390
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Basic Information
| ChEMBL ID | CHEMBL216390 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AQSNHHVBBFTCSC-UHFFFAOYSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
375.7
MW (Da)
1.53
ALogP
6
HBA
4
HBD
141.5
PSA (Ų)
0.51
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.0
Ki 1 meas. best 4.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA CHEMBL2093871 | Ki | 4.22 | 4.22 | 60000.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 4.0 | 4.0 | 100000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA | Ki | = | 60000.0 | nM | 4.22 | Displacement of [3H]AMPA from AMPA receptor in rat cortical synaptic membrane | 17004715 |
| Unchecked | IC50 | = | 100000.0 | nM | 4.0 | Displacement of [3H]KA from high affinity KA receptor in rat cortical membrane | 17004715 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17004715 | 10.1021/jm0604880 | Unchecked | 2 |
| 17004715 | 10.1021/jm0604880 | Glutamate receptor ionotropic, AMPA | 1 |
| 17004715 | 10.1021/jm0604880 | Glutamate NMDA receptor | 1 |
Data from ChEMBL 36 via Core Engine