Assay Detail
Binding
CHEMBL910041
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]ABA from human adenosine A1 receptor
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Tricyclic imidazoline derivatives as potent and selective adenosine A1 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.71 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL218458 | — | — | 1 | 8.70 |
| CHEMBL414157 | TONAPOFYLLINE | 3.0 | 1 | 8.15 |
| CHEMBL450341 | — | — | 1 | 7.66 |
| CHEMBL217268 | — | — | 1 | 7.46 |
| CHEMBL216269 | — | — | 1 | 7.46 |
| CHEMBL216200 | — | — | 1 | 7.35 |
| CHEMBL384279 | — | — | 1 | 7.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL218458 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL414157 | TONAPOFYLLINE | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL450341 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL217268 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL216269 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL216200 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL384279 | — | Ki | = | 60.0 | nM | 7.22 |