Assay Detail
Functional
CHEMBL910239
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Inhibition of cell proliferation in MCF7 mp53 cells in absence of 6.5 Gy [60Co]-induced DNA damage
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Inhibition of the G2 DNA damage checkpoint by oliveroline isolated from Duguetia odorata.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.48 | 4.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL220527 | DEHYDRODISCRETINE | — | 1 | 4.60 |
| CHEMBL221034 | OLIVEROLINE | — | 1 | 4.35 |
| CHEMBL376300 | PSEUDOPALMATINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL220527 | DEHYDRODISCRETINE | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL221034 | OLIVEROLINE | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL376300 | PSEUDOPALMATINE | IC50 | = | 250000.0 | nM | - |