Compound Detail
CHEMBL221034
OLIVEROLINE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL221034 |
| Name | OLIVEROLINE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NVMGTUCOAQKLLO-IRXDYDNUSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
295.3
MW (Da)
2.66
ALogP
4
HBA
1
HBD
41.9
PSA (Ų)
0.81
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 4.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| MCF7 CHEMBL387 | IC50 | 4.7 | 4.525 | 20000.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| MCF7 | IC50 | = | 20000.0 | nM | 4.7 | Inhibition of cell proliferation in MCF7 mp53 cells in presence of 6.5 Gy [60Co]... | 17315964 |
| MCF7 | IC50 | = | 45000.0 | nM | 4.35 | Inhibition of cell proliferation in MCF7 mp53 cells in absence of 6.5 Gy [60Co]-... | 17315964 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17315964 | 10.1021/np060285e | MCF7 | 5 |
| 17315964 | 10.1021/np060285e | Serine/threonine-protein kinase Chk1 | 1 |
Data from ChEMBL 36 via Core Engine