Assay Detail
Binding
CHEMBL910293
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Plasmodium falciparum PFT
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 7 — Homologous single protein target |
| Curated By | Intermediate |
Target
Protein farnesyltransferase (PFT) (CHEMBL2111381) ↗| Type | PROTEIN COMPLEX |
| Organism | Plasmodium falciparum |
Publication
Structurally simple, potent, Plasmodium selective farnesyltransferase inhibitors that arrest the growth of malaria parasites.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 8.18 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL215769 | — | — | 1 | 9.30 |
| CHEMBL214610 | — | — | 1 | 9.22 |
| CHEMBL215229 | — | — | 1 | 8.72 |
| CHEMBL215083 | — | — | 1 | 8.70 |
| CHEMBL385845 | — | — | 1 | 8.68 |
| CHEMBL379766 | — | — | 1 | 8.35 |
| CHEMBL213330 | — | — | 1 | 8.10 |
| CHEMBL384373 | — | — | 1 | 8.05 |
| CHEMBL383966 | — | — | 1 | 7.26 |
| CHEMBL215780 | — | — | 1 | 7.02 |
| CHEMBL386292 | — | — | 1 | 6.62 |
| CHEMBL211989 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL215769 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL214610 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL215229 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL215083 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL385845 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL379766 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL213330 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL384373 | — | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL383966 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL215780 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL386292 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL211989 | — | IC50 | > | 1000.0 | nM | - |