Assay Detail
Binding
CHEMBL910294
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Inhibition of rat PFT
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Protein farnesyltransferase (CHEMBL2095197) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Structurally simple, potent, Plasmodium selective farnesyltransferase inhibitors that arrest the growth of malaria parasites.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.17 | 8.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL379766 | — | — | 1 | 8.12 |
| CHEMBL384373 | — | — | 1 | 7.89 |
| CHEMBL214610 | — | — | 1 | 7.81 |
| CHEMBL215769 | — | — | 1 | 7.60 |
| CHEMBL385845 | — | — | 1 | 7.37 |
| CHEMBL215229 | — | — | 1 | 7.08 |
| CHEMBL383966 | — | — | 1 | 6.75 |
| CHEMBL215083 | — | — | 1 | 6.54 |
| CHEMBL215780 | — | — | 1 | 6.46 |
| CHEMBL386292 | — | — | 1 | 6.06 |
| CHEMBL211989 | — | — | 1 | - |
| CHEMBL213330 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL379766 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL384373 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL214610 | — | IC50 | = | 15.5 | nM | 7.81 |
| CHEMBL215769 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL385845 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL215229 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL383966 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL215083 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL215780 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL386292 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL211989 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL213330 | — | IC50 | > | 1000.0 | nM | - |