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Assay Detail

CHEMBL910328

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human MetAP2
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Methionine aminopeptidase 2 (CHEMBL3922)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Fumarranol, a rearranged fumagillin analogue that inhibits angiogenesis in vivo.
Lu J, Chong CR, Hu X, Liu JO.
J Med Chem (2006) 49 : 5645 -5648
PubMed 16970390 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 6 5.53 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL424278 O-CHLOROACETYLCARBAMOYLFUMAGILLOL 2.0 1 9.00
CHEMBL387282 FUMARRANOL 1 5.49
CHEMBL266853 FUMAGALONE 1 5.10
CHEMBL215931 1 4.88
CHEMBL213526 1 4.47
CHEMBL214053 1 4.24

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL424278 O-CHLOROACETYLCARBAMOYLFUMAGILLOL IC50 = 1.0 nM 9.00
CHEMBL387282 FUMARRANOL IC50 = 3230.0 nM 5.49
CHEMBL266853 FUMAGALONE IC50 = 8000.0 nM 5.10
CHEMBL215931 IC50 = 13200.0 nM 4.88
CHEMBL213526 IC50 = 33800.0 nM 4.47
CHEMBL214053 IC50 = 57500.0 nM 4.24