Assay Detail
Binding
CHEMBL910511
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Staphylococcus aureus DNA gyrase by supercoiling assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Isothiazoloquinolones with enhanced antistaphylococcal activities against multidrug-resistant strains: effects of structural modifications at the 6-, 7-, and 8-positions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.24 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL219534 | — | — | 1 | 5.80 |
| CHEMBL219216 | — | — | 1 | 5.70 |
| CHEMBL436512 | — | — | 1 | 5.68 |
| CHEMBL220656 | — | — | 1 | 5.50 |
| CHEMBL430 | GEMIFLOXACIN | 4.0 | 1 | 5.25 |
| CHEMBL32 | MOXIFLOXACIN | 4.0 | 1 | 4.55 |
| CHEMBL8 | CIPROFLOXACIN | 4.0 | 1 | 4.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL219534 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL219216 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL436512 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL220656 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL430 | GEMIFLOXACIN | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL32 | MOXIFLOXACIN | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL8 | CIPROFLOXACIN | IC50 | = | 62000.0 | nM | 4.21 |