Assay Detail
Binding
CHEMBL910641
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Displacement of [125I]apamin from Wistar rat cortical apamin-sensitive site
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Small conductance calcium-activated potassium channel (CHEMBL2096673) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Synthesis and radioligand binding studies of methoxylated 1,2,3,4-tetrahydroisoquinolinium derivatives as ligands of the apamin-sensitive Ca2+-activated K+ channels.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.67 | 6.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL215533 | — | — | 1 | 6.14 |
| CHEMBL215029 | — | — | 1 | 6.04 |
| CHEMBL215370 | LAUDANOSINE METHIODIDE | — | 1 | 5.89 |
| CHEMBL215037 | — | — | 1 | 5.66 |
| CHEMBL386836 | — | — | 1 | 5.44 |
| CHEMBL214787 | — | — | 1 | 5.27 |
| CHEMBL215382 | — | — | 1 | 5.24 |
| CHEMBL525408 | APAMIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL215533 | — | Ki | = | 730.0 | nM | 6.14 |
| CHEMBL215029 | — | Ki | = | 910.0 | nM | 6.04 |
| CHEMBL215370 | LAUDANOSINE METHIODIDE | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL215037 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL386836 | — | Ki | = | 3600.0 | nM | 5.44 |
| CHEMBL214787 | — | Ki | = | 5400.0 | nM | 5.27 |
| CHEMBL215382 | — | Ki | = | 5800.0 | nM | 5.24 |
| CHEMBL525408 | APAMIN | Ki | = | 0.0038 | nM | - |