Assay Detail
Binding
CHEMBL910643
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Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat hippocampus
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Hippocampus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
WB4101-related compounds: new, subtype-selective alpha1-adrenoreceptor antagonists (or inverse agonists?).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 6.93 | 8.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL215421 | — | — | 1 | 8.61 |
| CHEMBL215151 | — | — | 1 | 8.16 |
| CHEMBL383938 | — | — | 1 | 8.07 |
| CHEMBL217469 | — | — | 1 | 7.95 |
| CHEMBL214986 | — | — | 1 | 7.39 |
| CHEMBL214694 | — | — | 1 | 7.28 |
| CHEMBL439346 | — | — | 1 | 7.17 |
| CHEMBL214762 | — | — | 1 | 7.13 |
| CHEMBL214952 | — | — | 1 | 7.11 |
| CHEMBL217143 | — | — | 1 | 6.88 |
| CHEMBL215188 | — | — | 1 | 6.46 |
| CHEMBL214552 | — | — | 1 | 6.44 |
| CHEMBL218079 | — | — | 1 | 6.44 |
| CHEMBL215857 | — | — | 1 | 6.30 |
| CHEMBL214506 | — | — | 1 | 6.06 |
| CHEMBL436955 | — | — | 1 | 6.00 |
| CHEMBL385371 | — | — | 1 | 5.77 |
| CHEMBL218732 | — | — | 1 | 5.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL215421 | — | Ki | = | 2.455 | nM | 8.61 |
| CHEMBL215151 | — | Ki | = | 6.918 | nM | 8.16 |
| CHEMBL383938 | — | Ki | = | 8.511 | nM | 8.07 |
| CHEMBL217469 | — | Ki | = | 11.22 | nM | 7.95 |
| CHEMBL214986 | — | Ki | = | 40.74 | nM | 7.39 |
| CHEMBL214694 | — | Ki | = | 52.48 | nM | 7.28 |
| CHEMBL439346 | — | Ki | = | 67.61 | nM | 7.17 |
| CHEMBL214762 | — | Ki | = | 74.13 | nM | 7.13 |
| CHEMBL214952 | — | Ki | = | 77.62 | nM | 7.11 |
| CHEMBL217143 | — | Ki | = | 131.83 | nM | 6.88 |
| CHEMBL215188 | — | Ki | = | 346.74 | nM | 6.46 |
| CHEMBL214552 | — | Ki | = | 363.08 | nM | 6.44 |
| CHEMBL218079 | — | Ki | = | 363.08 | nM | 6.44 |
| CHEMBL215857 | — | Ki | = | 501.19 | nM | 6.30 |
| CHEMBL214506 | — | Ki | = | 870.96 | nM | 6.06 |
| CHEMBL436955 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL385371 | — | Ki | = | 1698.24 | nM | 5.77 |
| CHEMBL218732 | — | Ki | = | 3630.78 | nM | 5.44 |