Assay Detail
Functional
CHEMBL910644
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Blockade of apamin-sensitive AHP in Wistar rat dopaminergic neurons by electrophysiology assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Neuron |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and radioligand binding studies of methoxylated 1,2,3,4-tetrahydroisoquinolinium derivatives as ligands of the apamin-sensitive Ca2+-activated K+ channels.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.94 | 5.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL215533 | — | — | 1 | 5.05 |
| CHEMBL215370 | LAUDANOSINE METHIODIDE | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL215533 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL215370 | LAUDANOSINE METHIODIDE | IC50 | = | 15000.0 | nM | 4.82 |