Assay Detail
Binding
CHEMBL910656
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Inhibition of beta-hematin polymerization
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Histidine-rich protein PFHRP-II (CHEMBL1923) ↗| Type | SINGLE PROTEIN |
| Organism | Plasmodium falciparum |
Publication
Synthesis and antimalarial activity of side chain modified 4-aminoquinoline derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 6.16 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL218854 | — | — | 1 | 6.62 |
| CHEMBL219189 | — | — | 1 | 6.41 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.40 |
| CHEMBL374418 | — | — | 1 | 6.35 |
| CHEMBL376236 | — | — | 1 | 6.34 |
| CHEMBL219967 | — | — | 1 | 6.34 |
| CHEMBL219444 | — | — | 1 | 6.33 |
| CHEMBL218312 | — | — | 1 | 6.31 |
| CHEMBL376916 | — | — | 1 | 6.25 |
| CHEMBL218531 | — | — | 1 | 6.24 |
| CHEMBL375375 | — | — | 1 | 6.21 |
| CHEMBL218530 | — | — | 1 | 6.19 |
| CHEMBL222016 | — | — | 1 | 6.19 |
| CHEMBL219436 | — | — | 1 | 6.12 |
| CHEMBL219031 | — | — | 1 | 6.12 |
| CHEMBL219398 | — | — | 1 | 6.11 |
| CHEMBL219488 | — | — | 1 | 6.07 |
| CHEMBL219397 | — | — | 1 | 6.06 |
| CHEMBL375612 | — | — | 1 | 6.05 |
| CHEMBL219109 | — | — | 1 | 6.05 |
| CHEMBL218897 | — | — | 1 | 6.04 |
| CHEMBL219009 | — | — | 1 | 6.03 |
| CHEMBL219537 | — | — | 1 | 6.02 |
| CHEMBL219517 | — | — | 1 | 6.02 |
| CHEMBL425990 | — | — | 1 | 6.02 |
| CHEMBL220134 | — | — | 1 | 6.01 |
| CHEMBL222017 | — | — | 1 | 6.01 |
| CHEMBL218389 | — | — | 1 | 6.01 |
| CHEMBL385783 | — | — | 1 | 6.00 |
| CHEMBL373799 | — | — | 1 | 5.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL218854 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL219189 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL374418 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL376236 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL219967 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL219444 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL218312 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL376916 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL218531 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL375375 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL218530 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL222016 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL219436 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL219031 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL219398 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL219488 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL219397 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL375612 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL219109 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL218897 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL219009 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL219537 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL219517 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL425990 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL220134 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL222017 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL218389 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL385783 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL373799 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL219395 | — | IC50 | = | 1050.0 | nM | 5.98 |