Assay Detail
ADMET
CHEMBL910777
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Cytotoxicity against PC3 cell line by MTT assay
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Evaluation of the tubulin-bound paclitaxel conformation: synthesis, biology, and SAR studies of C-4 to C-3' bridged paclitaxel analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 7.24 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4649912 | — | — | 1 | 8.89 |
| CHEMBL4649910 | — | — | 1 | 8.82 |
| CHEMBL219213 | — | — | 1 | 8.62 |
| CHEMBL373681 | — | — | 1 | 8.60 |
| CHEMBL4649913 | — | — | 1 | 8.51 |
| CHEMBL4649915 | — | — | 1 | 8.49 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.30 |
| CHEMBL4649909 | — | — | 1 | 8.22 |
| CHEMBL4649914 | — | — | 1 | 8.09 |
| CHEMBL4649911 | — | — | 1 | 7.96 |
| CHEMBL414338 | — | — | 1 | 7.89 |
| CHEMBL4649905 | — | — | 1 | 7.82 |
| CHEMBL4649917 | — | — | 1 | 7.80 |
| CHEMBL4649902 | — | — | 1 | 7.47 |
| CHEMBL435148 | — | — | 1 | 7.30 |
| CHEMBL219214 | — | — | 1 | 7.29 |
| CHEMBL269320 | — | — | 1 | 7.28 |
| CHEMBL374763 | — | — | 1 | 7.26 |
| CHEMBL4649918 | — | — | 1 | 7.26 |
| CHEMBL373923 | — | — | 1 | 7.05 |
| CHEMBL435147 | — | — | 1 | 6.89 |
| CHEMBL438643 | — | — | 1 | 6.56 |
| CHEMBL218523 | — | — | 1 | 6.50 |
| CHEMBL415210 | — | — | 1 | 6.41 |
| CHEMBL376867 | — | — | 1 | 6.30 |
| CHEMBL437730 | — | — | 1 | 6.26 |
| CHEMBL384216 | — | — | 1 | 6.26 |
| CHEMBL414340 | — | — | 1 | 6.24 |
| CHEMBL4649908 | — | — | 1 | 6.24 |
| CHEMBL414339 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4649912 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4649910 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL219213 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL373681 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL4649913 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL4649915 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4649909 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4649914 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL4649911 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL414338 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4649905 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4649917 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4649902 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL435148 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL219214 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL269320 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL4649918 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL374763 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL373923 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL435147 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL438643 | — | IC50 | = | 275.0 | nM | 6.56 |
| CHEMBL218523 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL415210 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL376867 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL437730 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL384216 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL414340 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL4649908 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL414339 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL218612 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL437327 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL374764 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4649906 | — | IC50 | - | — | - | |
| CHEMBL4649899 | — | IC50 | - | — | - | |
| CHEMBL385780 | — | IC50 | > | 13200.0 | nM | - |