Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL4649909

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
COc1cccc(C(=O)O[C@H]2[C@@H]3[C@]45CO[C@@H]4C[C@H](O)[C@@]3(C)C(=O)[C@H](OC(C)=O)C3=C(C)[C@H](C[C@]2(O)C3(C)C)OC(=O)[C@H](O)[C@@H](NC(=O)c2ccccc2)c2ccccc2/C=C/CC(=O)O5)c1

Basic Information

ChEMBL ID CHEMBL4649909
Phase Preclinical
Structure Type MOL
InChI Key YHRQJZFMAFUUNW-SNXSWICQSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

908.0
MW (Da)
4.14
ALogP
15
HBA
4
HBD
230.5
PSA (Ų)
0.15
QED
2
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C50H53NO15
MW 907.97
Aromatic Rings 3
Heavy Atoms 66
NP-Likeness 1.68

Activity Summary

IC50 2 meas. best 8.22

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
PC-3
CHEMBL390
IC50 8.22 8.22 6.0 1
A2780
CHEMBL614004
IC50 7.62 7.62 23.7 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
PC-3 IC50 = 6.0 nM 8.22 Cytotoxicity against PC3 cell line by MTT assay 17263521
A2780 IC50 = 23.7 nM 7.62 Cytotoxicity against A2780 cell line 17263521

Literature References

PubMed DOI Target Context # Activities
17263521 10.1021/jm061071x A2780 1
17263521 10.1021/jm061071x PC-3 1
17263521 10.1021/jm061071x Tubulin 1

Data from ChEMBL 36 via Core Engine