Assay Detail
ADMET
CHEMBL910776
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Cytotoxicity against A2780 cell line
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Evaluation of the tubulin-bound paclitaxel conformation: synthesis, biology, and SAR studies of C-4 to C-3' bridged paclitaxel analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 6.78 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL373681 | — | — | 1 | 9.52 |
| CHEMBL4649912 | — | — | 1 | 9.31 |
| CHEMBL4649913 | — | — | 1 | 9.30 |
| CHEMBL219213 | — | — | 1 | 9.30 |
| CHEMBL4649910 | — | — | 1 | 9.19 |
| CHEMBL4649915 | — | — | 1 | 8.85 |
| CHEMBL4649905 | — | — | 1 | 7.84 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.82 |
| CHEMBL4649914 | — | — | 1 | 7.75 |
| CHEMBL435148 | — | — | 1 | 7.73 |
| CHEMBL4649917 | — | — | 1 | 7.70 |
| CHEMBL4649899 | — | — | 1 | 7.64 |
| CHEMBL4649909 | — | — | 1 | 7.62 |
| CHEMBL414338 | — | — | 1 | 7.55 |
| CHEMBL374763 | — | — | 1 | 6.46 |
| CHEMBL373923 | — | — | 1 | 6.36 |
| CHEMBL4649906 | — | — | 1 | 6.19 |
| CHEMBL4649902 | — | — | 1 | 6.17 |
| CHEMBL269320 | — | — | 1 | 6.16 |
| CHEMBL435147 | — | — | 1 | 6.11 |
| CHEMBL4649918 | — | — | 1 | 6.08 |
| CHEMBL219214 | — | — | 1 | 6.01 |
| CHEMBL437730 | — | — | 1 | 5.89 |
| CHEMBL438643 | — | — | 1 | 5.80 |
| CHEMBL218523 | — | — | 1 | 5.77 |
| CHEMBL376867 | — | — | 1 | 5.74 |
| CHEMBL384216 | — | — | 1 | 5.72 |
| CHEMBL415210 | — | — | 1 | 5.70 |
| CHEMBL218612 | — | — | 1 | 5.60 |
| CHEMBL414339 | — | — | 1 | 5.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL373681 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4649912 | — | IC50 | = | 0.49 | nM | 9.31 |
| CHEMBL219213 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL4649913 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL4649910 | — | IC50 | = | 0.65 | nM | 9.19 |
| CHEMBL4649915 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4649905 | — | IC50 | = | 14.5 | nM | 7.84 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4649914 | — | IC50 | = | 17.7 | nM | 7.75 |
| CHEMBL435148 | — | IC50 | = | 18.5 | nM | 7.73 |
| CHEMBL4649917 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4649899 | — | IC50 | = | 23.1 | nM | 7.64 |
| CHEMBL4649909 | — | IC50 | = | 23.7 | nM | 7.62 |
| CHEMBL414338 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL374763 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL373923 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL4649906 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL4649902 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL269320 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL435147 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL4649918 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL219214 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL437730 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL438643 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL218523 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL376867 | — | IC50 | = | 1840.0 | nM | 5.74 |
| CHEMBL384216 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL415210 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL218612 | — | IC50 | = | 2520.0 | nM | 5.60 |
| CHEMBL414339 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4649908 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL374764 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL414340 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL437327 | — | IC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL385780 | — | IC50 | = | 19800.0 | nM | 4.70 |
| CHEMBL4649911 | — | IC50 | > | 6.0 | nM | - |