Assay Detail
Binding
CHEMBL910785
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Plasmodium falciparum ENR
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Enoyl-acyl-carrier protein reductase (CHEMBL4150) ↗| Type | SINGLE PROTEIN |
| Organism | Plasmodium falciparum |
Publication
Green tea catechins potentiate triclosan binding to enoyl-ACP reductase from Plasmodium falciparum (PfENR).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.71 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | 3.0 | 1 | 6.60 |
| CHEMBL36327 | EPICATECHIN GALLATE | — | 1 | 6.30 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 5.60 |
| CHEMBL47386 | EPIGALLOCATECHIN | — | 1 | 5.16 |
| CHEMBL128000 | BUTEIN | — | 1 | 4.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL36327 | EPICATECHIN GALLATE | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL50 | QUERCETIN | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL47386 | EPIGALLOCATECHIN | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL128000 | BUTEIN | IC50 | = | 12500.0 | nM | 4.90 |