Assay Detail
Binding
CHEMBL911052
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]CP-55940 from CD1 mouse brain CB1 receptor
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Tricyclic pyrazoles. 4. Synthesis and biological evaluation of analogues of the robust and selective CB2 cannabinoid ligand 1-(2',4'-dichlorophenyl)-6-methyl-N-piperidin-1-yl-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxamide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 6.20 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL559612 | CP-55940 | — | 1 | 8.82 |
| CHEMBL381689 | SR-144528 | — | 1 | 7.16 |
| CHEMBL216276 | — | — | 1 | 6.44 |
| CHEMBL386014 | — | — | 1 | 6.08 |
| CHEMBL216735 | — | — | 1 | 6.05 |
| CHEMBL386644 | — | — | 1 | 6.04 |
| CHEMBL216595 | — | — | 1 | 5.92 |
| CHEMBL218957 | — | — | 1 | 5.69 |
| CHEMBL374889 | — | — | 1 | 5.64 |
| CHEMBL385268 | — | — | 1 | 5.62 |
| CHEMBL386858 | — | — | 1 | 5.58 |
| CHEMBL216335 | — | — | 1 | 5.35 |
| CHEMBL385151 | — | — | 1 | - |
| CHEMBL218432 | — | — | 1 | - |
| CHEMBL219578 | — | — | 1 | - |
| CHEMBL216333 | — | — | 1 | - |
| CHEMBL219037 | — | — | 1 | - |
| CHEMBL414366 | — | — | 1 | - |
| CHEMBL216659 | — | — | 1 | - |
| CHEMBL218571 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL559612 | CP-55940 | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL381689 | SR-144528 | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL216276 | — | Ki | = | 363.0 | nM | 6.44 |
| CHEMBL386014 | — | Ki | = | 833.0 | nM | 6.08 |
| CHEMBL216735 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL386644 | — | Ki | = | 916.0 | nM | 6.04 |
| CHEMBL216595 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL218957 | — | Ki | = | 2050.0 | nM | 5.69 |
| CHEMBL374889 | — | Ki | = | 2275.0 | nM | 5.64 |
| CHEMBL385268 | — | Ki | = | 2409.0 | nM | 5.62 |
| CHEMBL386858 | — | Ki | = | 2625.0 | nM | 5.58 |
| CHEMBL216335 | — | Ki | = | 4500.0 | nM | 5.35 |
| CHEMBL385151 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL218432 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL219578 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL216333 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL219037 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL414366 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL216659 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL218571 | — | Ki | > | 10000.0 | nM | - |