Assay Detail
Binding
CHEMBL911103
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Inhibition of human recombinant DHODH
27
Total Activities
14
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Dihydroorotate dehydrogenase (quinone), mitochondrial (CHEMBL1966) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and synthesis of potent inhibitors of the malaria parasite dihydroorotate dehydrogenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.56 | 6.58 |
| Ki | 13 | 5.21 | 7.57 |
| Km | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL387254 | — | — | 2 | 7.57 |
| CHEMBL973 | TERIFLUNOMIDE | 4.0 | 2 | 7.52 |
| CHEMBL218467 | — | — | 2 | 5.44 |
| CHEMBL217897 | — | — | 2 | 4.89 |
| CHEMBL435137 | — | — | 2 | 4.82 |
| CHEMBL219856 | — | — | 2 | 4.75 |
| CHEMBL413583 | — | — | 2 | 4.45 |
| CHEMBL217951 | — | — | 2 | 4.29 |
| CHEMBL218703 | — | — | 2 | 4.22 |
| CHEMBL217893 | — | — | 2 | 4.19 |
| CHEMBL219855 | — | — | 2 | - |
| CHEMBL373493 | — | — | 2 | - |
| CHEMBL374338 | — | — | 2 | - |
| CHEMBL217894 | DECYLUBIQUINONE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL387254 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL973 | TERIFLUNOMIDE | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL973 | TERIFLUNOMIDE | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL218467 | — | Ki | = | 3630.0 | nM | 5.44 |
| CHEMBL217897 | — | Ki | = | 12800.0 | nM | 4.89 |
| CHEMBL435137 | — | Ki | = | 15100.0 | nM | 4.82 |
| CHEMBL219856 | — | Ki | = | 17900.0 | nM | 4.75 |
| CHEMBL218467 | — | IC50 | = | 29570.0 | nM | 4.53 |
| CHEMBL413583 | — | Ki | = | 35900.0 | nM | 4.45 |
| CHEMBL217951 | — | Ki | = | 50900.0 | nM | 4.29 |
| CHEMBL218703 | — | Ki | = | 60400.0 | nM | 4.22 |
| CHEMBL217893 | — | Ki | = | 64400.0 | nM | 4.19 |
| CHEMBL387254 | — | IC50 | = | 219800.0 | nM | - |
| CHEMBL413583 | — | IC50 | = | 292200.0 | nM | - |
| CHEMBL219856 | — | IC50 | = | 145700.0 | nM | - |
| CHEMBL435137 | — | IC50 | = | 123300.0 | nM | - |
| CHEMBL218703 | — | IC50 | = | 491400.0 | nM | - |
| CHEMBL219855 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL373493 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL374338 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL219855 | — | Ki | - | — | - | |
| CHEMBL374338 | — | Ki | - | — | - | |
| CHEMBL373493 | — | Ki | - | — | - | |
| CHEMBL217951 | — | IC50 | = | 415400.0 | nM | - |
| CHEMBL217893 | — | IC50 | = | 524400.0 | nM | - |
| CHEMBL217897 | — | IC50 | = | 104200.0 | nM | - |
| CHEMBL217894 | DECYLUBIQUINONE | Km | = | 14000.0 | nM | - |