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Assay Detail

CHEMBL911128

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [125I]RTI-55 from human NET expressing HEK293 cells
ChEMBL ↗
55
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type HEK293
Confidence 9 — Direct single protein target
Curated By Expert

Target

Sodium-dependent noradrenaline transporter (CHEMBL222) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Slow-onset, long-duration, alkyl analogues of methylphenidate with enhanced selectivity for the dopamine transporter.
Froimowitz M, Gu Y, Dakin LA, Nagafuji PM, Kelley CJ, Parrish D, Deschamps JR, Janowsky A.
J Med Chem (2007) 50 : 219 -232
PubMed 17228864 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 55 6.15 8.41

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL219649 — — 2 8.41
CHEMBL374634 — — 2 7.92
CHEMBL220195 — — 2 7.85
CHEMBL219335 — — 2 7.64
CHEMBL218999 — — 2 7.60
CHEMBL219116 — — 2 6.96
CHEMBL219703 — — 2 6.80
CHEMBL387117 — — 2 6.72
CHEMBL218847 — — 2 6.70
CHEMBL218849 — — 2 6.64
CHEMBL376852 — — 2 6.44
CHEMBL219224 — — 2 6.44
CHEMBL375118 — — 2 6.42
CHEMBL441864 — — 2 6.31
CHEMBL370805 COCAINE 4.0 1 6.30
CHEMBL796 METHYLPHENIDATE 4.0 1 6.18
CHEMBL218848 — — 2 6.09
CHEMBL373710 — — 2 6.08
CHEMBL220247 — — 2 6.08
CHEMBL219334 — — 2 6.01
CHEMBL374769 — — 2 5.85
CHEMBL219653 — — 2 5.77
CHEMBL219281 — — 2 5.75
CHEMBL218193 — — 2 5.60
CHEMBL219540 — — 1 5.57
CHEMBL373773 — — 2 5.54
CHEMBL218894 — — 2 5.51
CHEMBL217975 — — 2 5.42
CHEMBL219707 — — 2 5.38

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL219649 — Ki = 3.9 nM 8.41
CHEMBL374634 — Ki = 12.0 nM 7.92
CHEMBL220195 — Ki = 14.0 nM 7.85
CHEMBL219335 — Ki = 23.0 nM 7.64
CHEMBL218999 — Ki = 25.0 nM 7.60
CHEMBL219649 — Ki = 30.0 nM 7.52
CHEMBL374634 — Ki = 31.0 nM 7.51
CHEMBL219116 — Ki = 110.0 nM 6.96
CHEMBL218999 — Ki = 120.0 nM 6.92
CHEMBL219703 — Ki = 160.0 nM 6.80
CHEMBL387117 — Ki = 190.0 nM 6.72
CHEMBL218847 — Ki = 200.0 nM 6.70
CHEMBL218849 — Ki = 230.0 nM 6.64
CHEMBL219335 — Ki = 340.0 nM 6.47
CHEMBL376852 — Ki = 360.0 nM 6.44
CHEMBL219224 — Ki = 360.0 nM 6.44
CHEMBL375118 — Ki = 380.0 nM 6.42
CHEMBL441864 — Ki = 490.0 nM 6.31
CHEMBL370805 COCAINE Ki = 500.0 nM 6.30
CHEMBL387117 — Ki = 660.0 nM 6.18
CHEMBL796 METHYLPHENIDATE Ki = 660.0 nM 6.18
CHEMBL218848 — Ki = 810.0 nM 6.09
CHEMBL373710 — Ki = 830.0 nM 6.08
CHEMBL220247 — Ki = 840.0 nM 6.08
CHEMBL219334 — Ki = 970.0 nM 6.01
CHEMBL374769 — Ki = 1400.0 nM 5.85
CHEMBL218847 — Ki = 1400.0 nM 5.85
CHEMBL219703 — Ki = 1500.0 nM 5.82
CHEMBL441864 — Ki = 1500.0 nM 5.82
CHEMBL218849 — Ki = 1600.0 nM 5.80
CHEMBL219653 — Ki = 1700.0 nM 5.77
CHEMBL219281 — Ki = 1800.0 nM 5.75
CHEMBL219281 — Ki = 2400.0 nM 5.62
CHEMBL218193 — Ki = 2500.0 nM 5.60
CHEMBL219653 — Ki = 2600.0 nM 5.58
CHEMBL219540 — Ki = 2700.0 nM 5.57
CHEMBL373773 — Ki = 2900.0 nM 5.54
CHEMBL218894 — Ki = 3100.0 nM 5.51
CHEMBL218193 — Ki = 3200.0 nM 5.50
CHEMBL375118 — Ki = 3300.0 nM 5.48
CHEMBL217975 — Ki = 3800.0 nM 5.42
CHEMBL373773 — Ki = 4000.0 nM 5.40
CHEMBL220195 — Ki = 4200.0 nM 5.38
CHEMBL219707 — Ki = 4200.0 nM 5.38
CHEMBL219334 — Ki = 4300.0 nM 5.37
CHEMBL219707 — Ki = 4300.0 nM 5.37
CHEMBL220247 — Ki = 4500.0 nM 5.35
CHEMBL217975 — Ki = 12000.0 nM 4.92
CHEMBL373710 — Ki = 12000.0 nM 4.92
CHEMBL218894 — Ki = 16000.0 nM 4.80