Assay Detail
Functional
CHEMBL911186
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human androgen receptor in CV1 cells measured as stimulation of luciferase reporter gene activity by cotransfection assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CV-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of 6-N,N-bis(2,2,2-trifluoroethyl)amino- 4-trifluoromethylquinolin-2(1H)-one as a novel selective androgen receptor modulator.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 8.12 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL436784 | — | — | 1 | 9.70 |
| CHEMBL217769 | — | — | 1 | 9.40 |
| CHEMBL442240 | — | — | 1 | 8.82 |
| CHEMBL217324 | — | — | 1 | 8.72 |
| CHEMBL277378 | — | — | 1 | 8.68 |
| CHEMBL217402 | — | — | 1 | 8.66 |
| CHEMBL267260 | — | — | 1 | 8.55 |
| CHEMBL27769 | STANOLONE | 2.0 | 1 | 8.29 |
| CHEMBL217428 | — | — | 1 | 6.97 |
| CHEMBL216949 | — | — | 1 | 5.89 |
| CHEMBL405835 | — | — | 1 | 5.69 |
| CHEMBL217168 | — | — | 1 | - |
| CHEMBL385509 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL436784 | — | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL217769 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL442240 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL217324 | — | EC50 | = | 1.9 | nM | 8.72 |
| CHEMBL277378 | — | EC50 | = | 2.1 | nM | 8.68 |
| CHEMBL217402 | — | EC50 | = | 2.2 | nM | 8.66 |
| CHEMBL267260 | — | EC50 | = | 2.8 | nM | 8.55 |
| CHEMBL27769 | STANOLONE | EC50 | = | 5.1 | nM | 8.29 |
| CHEMBL217428 | — | EC50 | = | 106.0 | nM | 6.97 |
| CHEMBL216949 | — | EC50 | = | 1283.0 | nM | 5.89 |
| CHEMBL405835 | — | EC50 | = | 2022.0 | nM | 5.69 |
| CHEMBL217168 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL385509 | — | EC50 | > | 10000.0 | nM | - |