Assay Detail
Functional
CHEMBL911188
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity against human androgen receptor in CV1 cells measured as inhibition of DHT-stimulated luciferase reporter gene activity by cotransfection assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CV-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of 6-N,N-bis(2,2,2-trifluoroethyl)amino- 4-trifluoromethylquinolin-2(1H)-one as a novel selective androgen receptor modulator.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.58 | 7.78 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL217428 | — | — | 1 | 7.78 |
| CHEMBL385509 | — | — | 1 | 7.58 |
| CHEMBL405835 | — | — | 1 | 7.56 |
| CHEMBL216949 | — | — | 1 | 7.53 |
| CHEMBL217168 | — | — | 1 | 7.47 |
| CHEMBL436784 | — | — | 1 | - |
| CHEMBL267260 | — | — | 1 | - |
| CHEMBL217769 | — | — | 1 | - |
| CHEMBL217324 | — | — | 1 | - |
| CHEMBL217402 | — | — | 1 | - |
| CHEMBL442240 | — | — | 1 | - |
| CHEMBL277378 | — | — | 1 | - |
| CHEMBL27769 | STANOLONE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL217428 | — | IC50 | = | 16.5 | nM | 7.78 |
| CHEMBL385509 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL405835 | — | IC50 | = | 27.5 | nM | 7.56 |
| CHEMBL216949 | — | IC50 | = | 29.5 | nM | 7.53 |
| CHEMBL217168 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL436784 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL267260 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL217769 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL217324 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL217402 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL442240 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL277378 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL27769 | STANOLONE | IC50 | > | 10000.0 | nM | - |