Assay Detail
Binding
CHEMBL911207
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cathepsin K
7
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Identification of selective, nonpeptidic nitrile inhibitors of cathepsin s using the substrate activity screening method.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.07 | 6.37 |
| IC50 | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL385571 | — | — | 1 | 6.37 |
| CHEMBL386912 | — | — | 1 | 6.06 |
| CHEMBL387191 | — | — | 1 | 5.77 |
| CHEMBL3085035 | — | — | 2 | - |
| CHEMBL385857 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL385571 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL386912 | — | Ki | = | 880.0 | nM | 6.06 |
| CHEMBL387191 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL3085035 | — | Ki | > | 15000.0 | nM | - |
| CHEMBL385857 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL385857 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3085035 | — | IC50 | > | 15000.0 | nM | - |