Assay Detail
Binding
CHEMBL911209
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cathepsin S
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Identification of selective, nonpeptidic nitrile inhibitors of cathepsin s using the substrate activity screening method.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.91 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3085035 | — | — | 1 | 7.82 |
| CHEMBL387191 | — | — | 1 | 7.75 |
| CHEMBL385857 | — | — | 1 | 6.70 |
| CHEMBL385571 | — | — | 1 | 6.38 |
| CHEMBL386912 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3085035 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL387191 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL385857 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL385571 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL386912 | — | Ki | = | 1200.0 | nM | 5.92 |