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Assay Detail

CHEMBL911221

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Binding
Inhibition of bovine erythrocyte AChE
27
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Confidence 9 — Direct single protein target
Curated By Expert

Target

Acetylcholinesterase (CHEMBL4768)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

Binding of 13-amidohuprines to acetylcholinesterase: exploring the ligand-induced conformational change of the gly117-gly118 peptide bond in the oxyanion hole.
Camps P, Gómez E, Muñoz-Torrero D, Badia A, Clos MV, Curutchet C, Muñoz-Muriedas J, Luque FJ.
J Med Chem (2006) 49 : 6833 -6840
PubMed 17154513 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 27 7.28 8.94

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2007996 1 8.94
CHEMBL483716 1 8.89
CHEMBL143812 1 8.56
CHEMBL4524111 2 8.46
CHEMBL140476 HUPRINE Y 1 8.37
CHEMBL536047 1 8.37
CHEMBL2374005 1 8.35
CHEMBL2374006 1 8.17
CHEMBL341658 1 8.13
CHEMBL322343 1 7.92
CHEMBL2374004 1 7.56
CHEMBL325338 1 7.42
CHEMBL2374003 1 7.33
CHEMBL322281 1 7.19
CHEMBL395280 HUPERZINE A 2.0 1 7.13
CHEMBL386541 2 6.93
CHEMBL95 TACRINE 4.0 1 6.89
CHEMBL384563 2 6.79
CHEMBL415799 2 6.41
CHEMBL217521 1 5.88
CHEMBL214467 2 5.77
CHEMBL387188 1 5.25

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2007996 IC50 = 1.15 nM 8.94
CHEMBL483716 IC50 = 1.3 nM 8.89
CHEMBL143812 IC50 = 2.77 nM 8.56
CHEMBL4524111 IC50 = 3.49 nM 8.46
CHEMBL140476 HUPRINE Y IC50 = 4.23 nM 8.37
CHEMBL536047 IC50 = 4.23 nM 8.37
CHEMBL2374005 IC50 = 4.5 nM 8.35
CHEMBL2374006 IC50 = 6.73 nM 8.17
CHEMBL341658 IC50 = 7.4 nM 8.13
CHEMBL4524111 IC50 = 8.51 nM 8.07
CHEMBL322343 IC50 = 12.0 nM 7.92
CHEMBL2374004 IC50 = 27.4 nM 7.56
CHEMBL325338 IC50 = 38.5 nM 7.42
CHEMBL2374003 IC50 = 47.1 nM 7.33
CHEMBL322281 IC50 = 65.0 nM 7.19
CHEMBL395280 HUPERZINE A IC50 = 74.0 nM 7.13
CHEMBL386541 IC50 = 118.0 nM 6.93
CHEMBL95 TACRINE IC50 = 130.0 nM 6.89
CHEMBL384563 IC50 = 161.0 nM 6.79
CHEMBL415799 IC50 = 389.0 nM 6.41
CHEMBL415799 IC50 = 482.0 nM 6.32
CHEMBL384563 IC50 = 741.0 nM 6.13
CHEMBL217521 IC50 = 1317.0 nM 5.88
CHEMBL386541 IC50 = 1370.0 nM 5.86
CHEMBL214467 IC50 = 1687.0 nM 5.77
CHEMBL214467 IC50 = 3585.0 nM 5.45
CHEMBL387188 IC50 = 5684.0 nM 5.25