Assay Detail
Binding
CHEMBL911223
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Inhibition of human serum BChE
13
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Binding of 13-amidohuprines to acetylcholinesterase: exploring the ligand-induced conformational change of the gly117-gly118 peptide bond in the oxyanion hole.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.84 | 7.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.36 |
| CHEMBL536047 | — | — | 1 | 6.63 |
| CHEMBL415799 | — | — | 2 | 6.22 |
| CHEMBL384563 | — | — | 2 | 5.40 |
| CHEMBL214467 | — | — | 2 | 5.07 |
| CHEMBL217521 | — | — | 1 | 5.04 |
| CHEMBL395280 | HUPERZINE A | 2.0 | 1 | - |
| CHEMBL387188 | — | — | 1 | - |
| CHEMBL386541 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95 | TACRINE | IC50 | = | 43.9 | nM | 7.36 |
| CHEMBL536047 | — | IC50 | = | 236.0 | nM | 6.63 |
| CHEMBL415799 | — | IC50 | = | 601.0 | nM | 6.22 |
| CHEMBL384563 | — | IC50 | = | 3980.0 | nM | 5.40 |
| CHEMBL415799 | — | IC50 | = | 6480.0 | nM | 5.19 |
| CHEMBL214467 | — | IC50 | = | 8490.0 | nM | 5.07 |
| CHEMBL217521 | — | IC50 | = | 9220.0 | nM | 5.04 |
| CHEMBL384563 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL395280 | HUPERZINE A | IC50 | > | 10000.0 | nM | - |
| CHEMBL387188 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL386541 | — | IC50 | - | — | - | |
| CHEMBL386541 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL214467 | — | IC50 | > | 10000.0 | nM | - |