Assay Detail
Binding
CHEMBL911273
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Displacement of [3H]PK 11195 from peripheral-type benzodiazepine receptor in rat kidney mitochondrial membranes
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
New fluorescent 2-phenylindolglyoxylamide derivatives as probes targeting the peripheral-type benzodiazepine receptor: design, synthesis, and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.72 | 9.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53430 | — | — | 1 | 9.43 |
| CHEMBL54349 | ALPIDEM | 4.0 | 1 | 9.30 |
| CHEMBL481537 | PK-11195 | — | 1 | 8.03 |
| CHEMBL374574 | — | — | 1 | 7.92 |
| CHEMBL384328 | — | — | 1 | 7.77 |
| CHEMBL286346 | RO-54864 | — | 1 | 7.64 |
| CHEMBL386903 | — | — | 1 | 7.64 |
| CHEMBL425811 | — | — | 1 | 7.38 |
| CHEMBL265039 | — | — | 1 | 6.08 |
| CHEMBL220306 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53430 | — | Ki | = | 0.37 | nM | 9.43 |
| CHEMBL54349 | ALPIDEM | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL481537 | PK-11195 | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL374574 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL384328 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL286346 | RO-54864 | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL386903 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL425811 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL265039 | — | Ki | = | 835.0 | nM | 6.08 |
| CHEMBL220306 | — | Ki | = | 994.0 | nM | 6.00 |