Assay Detail
Binding
CHEMBL911274
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of human PPARalpha by GST pull down assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Peroxisome proliferator-activated receptor alpha (CHEMBL239) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel sulfamide analogs of oleoylethanolamide showing in vivo satiety inducing actions and PPARalpha activation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 6.00 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL219156 | — | — | 1 | 7.00 |
| CHEMBL280065 | OLEOYLETHANOLAMIDE | — | 1 | 6.96 |
| CHEMBL374948 | — | — | 1 | 6.28 |
| CHEMBL295416 | PIRINIXIC ACID | 2.0 | 1 | 6.13 |
| CHEMBL571044 | — | — | 1 | 4.96 |
| CHEMBL387094 | — | — | 1 | 4.68 |
| CHEMBL218794 | — | — | 1 | - |
| CHEMBL218795 | — | — | 1 | - |
| CHEMBL218643 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL219156 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL280065 | OLEOYLETHANOLAMIDE | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL374948 | — | EC50 | = | 524.0 | nM | 6.28 |
| CHEMBL295416 | PIRINIXIC ACID | EC50 | = | 740.0 | nM | 6.13 |
| CHEMBL571044 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL387094 | — | EC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL218794 | — | EC50 | > | 10000000.0 | nM | - |
| CHEMBL218795 | — | EC50 | > | 10000000.0 | nM | - |
| CHEMBL218643 | — | EC50 | > | 10000000.0 | nM | - |