Assay Detail
Binding
CHEMBL911283
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Inhibition of full length human recombinant CA VI
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 34 | 6.70 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL26 | SULPIRIDE | 3.0 | 1 | 9.10 |
| CHEMBL220491 | BRINZOLAMIDE | 4.0 | 1 | 9.05 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 8.00 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 8.00 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.96 |
| CHEMBL7146 | — | — | 1 | 7.62 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 7.37 |
| CHEMBL220492 | TOPIRAMATE | 4.0 | 1 | 7.35 |
| CHEMBL77517 | INDISULAM | 2.0 | 1 | 7.33 |
| CHEMBL266026 | — | — | 1 | 7.26 |
| CHEMBL268439 | — | — | 1 | 7.14 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 7.10 |
| CHEMBL6633 | — | — | 1 | 7.07 |
| CHEMBL73962 | BENZOLAMIDE | — | 1 | 7.03 |
| CHEMBL6853 | — | — | 1 | 7.02 |
| CHEMBL6685 | — | — | 1 | 6.99 |
| CHEMBL360356 | — | — | 1 | 6.94 |
| CHEMBL266240 | — | — | 1 | 6.22 |
| CHEMBL6753 | — | — | 1 | 6.13 |
| CHEMBL6705 | — | — | 1 | 6.11 |
| CHEMBL265674 | — | — | 1 | 6.10 |
| CHEMBL7087 | — | — | 1 | 6.09 |
| CHEMBL414 | CARZENIDE | 2.0 | 1 | 6.05 |
| CHEMBL21 | SULFANILAMIDE | 4.0 | 1 | 6.03 |
| CHEMBL418 | 2,4-DISULFAMYLTRIFLUOROMETHYLANILINE | — | 1 | 6.02 |
| CHEMBL268177 | — | — | 1 | 5.99 |
| CHEMBL176495 | — | — | 1 | 5.96 |
| CHEMBL7092 | — | — | 1 | 5.96 |
| CHEMBL7204 | — | — | 1 | 5.89 |
| CHEMBL574 | P-TOLUENESULFONAMIDE | 3.0 | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL26 | SULPIRIDE | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL220491 | BRINZOLAMIDE | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL7146 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL220492 | TOPIRAMATE | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL77517 | INDISULAM | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL266026 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL268439 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL6633 | — | Ki | = | 86.0 | nM | 7.07 |
| CHEMBL73962 | BENZOLAMIDE | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL6853 | — | Ki | = | 96.0 | nM | 7.02 |
| CHEMBL6685 | — | Ki | = | 103.0 | nM | 6.99 |
| CHEMBL360356 | — | Ki | = | 114.0 | nM | 6.94 |
| CHEMBL266240 | — | Ki | = | 608.0 | nM | 6.22 |
| CHEMBL6753 | — | Ki | = | 740.0 | nM | 6.13 |
| CHEMBL6705 | — | Ki | = | 772.0 | nM | 6.11 |
| CHEMBL265674 | — | Ki | = | 798.0 | nM | 6.10 |
| CHEMBL7087 | — | Ki | = | 813.0 | nM | 6.09 |
| CHEMBL414 | CARZENIDE | Ki | = | 887.0 | nM | 6.05 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 941.0 | nM | 6.03 |
| CHEMBL418 | 2,4-DISULFAMYLTRIFLUOROMETHYLANILINE | Ki | = | 955.0 | nM | 6.02 |
| CHEMBL268177 | — | Ki | = | 1024.0 | nM | 5.99 |
| CHEMBL176495 | — | Ki | = | 1090.0 | nM | 5.96 |
| CHEMBL7092 | — | Ki | = | 1097.0 | nM | 5.96 |
| CHEMBL7204 | — | Ki | = | 1275.0 | nM | 5.89 |
| CHEMBL574 | P-TOLUENESULFONAMIDE | Ki | = | 1582.0 | nM | 5.80 |
| CHEMBL6784 | — | Ki | = | 4150.0 | nM | 5.38 |
| CHEMBL6724 | — | Ki | = | 4680.0 | nM | 5.33 |
| CHEMBL419 | MAFENIDE | Ki | = | 4800.0 | nM | 5.32 |
| CHEMBL6919 | — | Ki | = | 6680.0 | nM | 5.17 |