Assay Detail
Binding
CHEMBL911374
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ADAM10
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Disintegrin and metalloproteinase domain-containing protein 10 (CHEMBL5028) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a potent, selective, and orally active human epidermal growth factor receptor-2 sheddase inhibitor for the treatment of cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.86 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL375418 | — | — | 1 | 7.64 |
| CHEMBL373532 | — | — | 1 | 7.48 |
| CHEMBL434567 | — | — | 1 | 7.23 |
| CHEMBL219105 | — | — | 1 | 7.11 |
| CHEMBL221698 | — | — | 1 | 7.01 |
| CHEMBL221120 | — | — | 1 | 6.96 |
| CHEMBL221857 | — | — | 1 | 6.92 |
| CHEMBL373853 | — | — | 1 | 6.89 |
| CHEMBL387202 | — | — | 1 | 6.51 |
| CHEMBL219104 | — | — | 1 | 6.50 |
| CHEMBL426388 | — | — | 1 | 6.48 |
| CHEMBL221537 | — | — | 1 | 6.32 |
| CHEMBL218586 | — | — | 1 | 6.14 |
| CHEMBL220501 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL375418 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL373532 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL434567 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL219105 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL221698 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL221120 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL221857 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL373853 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL387202 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL219104 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL426388 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL221537 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL218586 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL220501 | — | IC50 | > | 5000.0 | nM | - |